Why do cells become insulin resistant?
Cells become insulin resistant because they are trying to
protect themselves from the toxic effects of high insulin. They
down regulate their receptor activity and number of receptors so
that they don‘t have to listen to those noxious stimuli all
the time. It is like having this loud, disgusting music played and
you want to turn the volume down.
You might think of insulin resistance as similar to sitting in a smelly room and pretty soon you don‘t smell it anymore because you get desensitized.