intestinal bacteria composition on a high fat diet
I read that a high fat diet changes the composition of intestinal bacteria towards the unhealthy types that produce high level of of endotoxin that in turn drives inflammation and promotes diseases of aging. That's a serious concern. What is your comment on that? What measures would you undertake to keep the bacterial populations down? Would antibiotics be one of them?
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Support Staff 1 Posted by Fiona on 23 Mar, 2012 08:07 PM
The first step would be taking out of your diet all the oils that are high in omega 6 as they become rancid quicker and thus leads to inflammation. Oils like safflower, sunflower, peanut, etc should not be taken. Ghee, organic butter, coconut oil, olive oil, oil from nuts and avocados are all great.
Best of health.
2 Posted by Natalie on 24 Mar, 2012 06:15 AM
So what you're saying, only omega 6 oils change the composition of intestinal bacteria toward the unhealthy types that drive the inflammation by their endotoxin? what about omega 3? I heard those were the most unstable and quickest to go rancid. Are you sure of your sources of info?
It is well known that the healthy types of bacteria are supported by stuff like FOS and certain starches, but mostly fiber, all of which are of plant origin. A ketogenic paleo diet is high in fat and low in starches and fiber, promoting the growth of unhealthy gut bacteria. The toxins produced by such bacteria in the gut have far more negative consequences on health than even an occasional rancid oil in the diet (of which we are NOT taking about here, by the way).
So my question remains: what do you propose to mediate the toxic effects of gut bacteria promoted by a high fat diet? I personally was thinking about occasional antibiotics to keep the gut bacterial populations low.
Support Staff 3 Posted by Ken on 26 Jan, 2013 10:33 PM
This is an older post but it seems that there is some interest in it, so I thought I would do a little commenting.
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Comment Requested
I read that a high fat diet changes the composition of intestinal bacteria towards the unhealthy types that produce high level of of endotoxin that in turn drives inflammation and promotes diseases of aging. That's a serious concern. What is your comment on that? What measures would you undertake to keep the bacterial
populations down? Would antibiotics be one of them?
Requested Comment Provided
The first step would be taking out of your diet all the oils that are high in omega 6 as they become rancid quicker and thus leads to inflammation.
Oils like safflower, sunflower, peanut, etc should not be taken. Ghee, organic butter, coconut oil, olive oil, oil from nuts and avocados are all great.
So what you're saying, only omega 6 oils change the composition of intestinal bacteria toward the unhealthy types that drive the inflammation by their endotoxin?
what about omega 3? I heard those were the most unstable and quickest to go rancid. Are you sure of your sources of info?
It is well known that the healthy types of bacteria are supported by stuff like FOS and certain starches, but mostly fiber, all of which are of plant origin.
A ketogenic paleo diet is high in fat and low in starches and fiber, promoting the growth of unhealthy gut bacteria. The toxins produced by such bacteria in the gut
have far more negative consequences on health than even an occasional rancid oil in the diet (of which we are NOT taking about here, by the way).
—————
Answer already provided — see above
So my question remains: what do you propose to mediate the toxic effects of gut bacteria promoted by a high fat diet? I personally was thinking about occasional antibiotics to keep the gut bacterial populations low.
• personally — we all have choices that on a personal basis, we choose to act upon.
• occasional antibiotics — I wonder, what is the name of the occasional antibiotics?
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I have **heard and read many things over the last 60 plus years.**
• Things like, there is going to be a major earthquake in my area in a few days — the media was all over the place, schools were shut down, parents and students were afraid. Well those *supposed few days has now turned into 20 plus years.*
••••••••
• I was having problems with diabetes, high blood pressure, and my liver, so I went in search of info & help.
• I came across Dr. Rosedale's website June 2012 and my life for, the better, has changed forever.
I can not disprove what Dr. Rosedale has to say but I can sure prove with my personal lab results and photos, that his Health Plan has merit.
In Dr. Rosedale's book you can find on,
• pages: 9, 63, 66-67, 70-71, 148 — info about omega 3 and omega 6
• pages: 152-153 — info about gastrointestinal health, preventing bacterial translocation from the gut, fuel for the mucosal & immune cells in the small intestine
••••••••
Below is some information that I have read but can not prove or disprove, it is just something I have read
Links are also provided …
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Preventing inflammatory bowel disease
Another indicator that bacteria help train the immune system is the epidemiology of Inflammatory Bowel Disease, or IBD, such as Crohn's Disease (CD). Some authors suggest that
SCFAs prevent IBD. In addition, some forms of bacteria can prevent inflammation. The incidence and prevalence of IBD is high in industrialized countries with a high standard of living and low in less economically developed countries, having increased in developed countries throughout the twentieth century. The disease is also linked to good hygiene in youth; lack of breastfeeding; and consumption of large amounts of sucrose and animal fat. Its incidence is inversely linked with poor sanitation during the first years of life and consumption of fruits, vegetables, and unprocessed foods. Also, the use of antibiotics, which kill native gut flora and harmful infectious pathogens alike, especially during childhood, is associated with inflammatory bowel disease. On the other hand, using probiotics, bacteria consumed as part of the diet that impart health benefits (aside from just nutrition),
helps treat IBD.]
Alterations in flora balance Effects of antibiotic use
Altering the numbers of gut bacteria, for example by taking broad-spectrum antibiotics, may affect the host's health and ability to digest food. People may take the drugs to cure bacterial illnesses or may unintentionally consume significant amounts of antibiotics by eating the meat of animals to which they were fed. Antibiotics can cause antibiotic-associated diarrhea (AAD) by irritating the bowel directly, changing the levels of gut flora, or allowing pathogenic bacteria to grow. Another harmful effect of antibiotics is the increase in numbers of antibiotic-resistant bacteria found after their use, which, when they invade the host, cause illnesses that are difficult to treat with antibiotics.
Changing the numbers and species of gut flora can reduce the body's ability to ferment carbohydrates and metabolize bile acids and may cause diarrhea. Carbohydrates that are not broken down may absorb too much water and cause runny stools, or lack of SCFAs produced by gut flora could cause the diarrhea.
A reduction in levels of native bacterial species also disrupts their ability to inhibit the growth of harmful species such as C. difficile and Salmonella kedougou, and these species can get out of hand, though their overgrowth may be incidental and not be the true cause of diarrhea. Emerging treatment protocols for C. difficile infections involve fecal microbiota transplantation of donor feces. Initial reports of treatment describe success rates of 90%, with few side effects. Efficacy is speculated to result from restoring bacterial balances of bacteroides and firmicutes classes of bacteria.
Gut flora composition also changes in severe illnesses, due not only to antibiotic use but also to such factors as ischemia of the gut, failure to eat, and immune compromise. Negative effects from this have led to interest in selective digestive tract decontamination (SDD), a treatment to kill only pathogenic bacteria and allow the re-establishment of healthy ones.
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Antibiotics
Antibiotics taken for any type of infection may cause gastrointestinal problems such as cramping, bloating and diarrhea. This effect is not related to reduced stomach acid, but usually results because the antibiotics have killed off the good bacteria that are needed in the intestines.
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Antibiotics: Killing Off Beneficial Bacteria … for Good?
It’s an accepted concept by now that taking antibiotics in order to quell an infection disrupts the personal microbiome, the population of microorganisms that we all carry around in our guts, and which vastly outnumbers the cells that make up our bodies. That recognition supports our understanding of Clostridium difficile disease — killing the beneficial bacteria allows C. diff room to surge and produce an overload of toxins — as well as the intense interest in establishing a research program that could demonstrate experimentally whether the vast industry producing probiotic products is doing what it purports to do.
But implicit in that concept is the expectation that, after a while — after a course of antibiotics ends — the gut flora repopulate and their natural balance returns.
What if that expectation were wrong?
In a provocative editorial published this week in Nature, Martin Blaser of New York University’s Langone Medical Center argues that antibiotics’ impact on gut bacteria is permanent — and so serious in its long-term consequences that medicine should consider whether to restrict antibiotic prescribing to pregnant women and young children.
Early evidence from my lab and others hints that, sometimes, our friendly flora never fully recover. These long-term changes to the beneficial bacteria within people’s bodies may even increase our susceptibility to infections and disease. Overuse of antibiotics could be fuelling the dramatic increase in conditions such as obesity, type 1 diabetes, inflammatory bowel disease, allergies and asthma, which have more than doubled in many populations.
Among the findings he cites in support: The population-level observation that the incidence of infection with H. pylori, the bacterial cause of gastric ulcers, has declined over decades just as the incidence of esophageal cancer has risen. In addition, he offers his own research group’s observation that children who don’t acquire H. pylori are at greater risk of developing allergy and asthma, and their findings that eradicating H. pylori affects the production of the two hormones, ghrelin and leptin, that play a role in weight gain.
Are antibiotics to blame for the decline in H.pylori? Blaser points out that the organism is vulnerable to the same antibiotics that are prescribed to children for ear infections and colds — and that children routinely receive up to 20 courses of antibiotics before they reach adulthood. In addition, he says, one-third to one-half of women in the industrialized world receive antibiotics during pregnancy. Couple that with the increasingly large percentage of children born by Caesarean section — who by skipping their trip through the birth canal miss their first exposure to friendly bacteria — and the result, he says, is that “each generation… could be beginning life with a smaller endowment of ancient microbes than the last.”
Finally, he points to evidence that antibiotic use permanently changes the composition of the gut microbiome, altering the balance of bacterial species and maintaining resistant bacteria in the gut.
The function and influence of the microbiome — in the gut, on the skin and everywhere in the body — is a huge research issue right now, with the founding by the National Institutes of Health of the Human Microbiome Project, not to mention continuing debates over the accuracy of the “hygiene hypothesis” and speculation that altering gut flora could influence everything from obesity to depression. This proposal dovetails with those inquiries — and also (you knew I had to get there eventually) with ongoing concern about antibiotic over-use encouraging the emergence of resistant organisms.
It’s understood that antibiotics are already over-prescribed in adults and children; reining in over-prescribing is one of the most difficult tasks in controlling the spread of superbugs.
This new hypothesis, Blaser says, ought to put more force behind the push to reduce antibiotic overuse, especially in early life:
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Can Antibiotics Cause Intestinal Infection
Pathogens or harmful bacteria are the microscopic organisms that attack and affect the function of the gastrointestinal tract in the body. Usually, they are the cause of various diseases and stomach and/or intestinal infections. Your immune system is naturally strong enough to fight pathogens, but antibiotics prescribed for dozens of common ailments act as powerful immunosuppressants.
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Antibiotics Can Turn Gut Bacteria Against Us
Taking antibiotics for even a short period can have a long-lasting impact on the bacteria that naturally reside in our gut, according to a new review article.
And antibiotics even may turn natural gut bacteria against us in the war against drug-resistant microbes.
The drugs leave gut bacteria harboring antibiotic-resistance genes for up to two years after you take them, the researcher said.
This reservoir of drug-resistant bacteria increases the chances of resistance genes being handed along to harmful, disease-causing bacteria , aiding their survival.
Antibiotics can alter the composition of bacterial populations that live in the intestine, and allow micro-organisms that are naturally resistant to the antibiotic to flourish.
The impact of antibiotics on the normal gut flora had been thought to be short-term, with any disturbances being restored several weeks after treatment. But studies are showing high levels of resistance genes in gut microbes after just seven days of antibiotic treatment, and remaining for up to two years, even if the individual has taken no further antibiotics.
The consequences of this could be potentially life-threatening, explained Dr. Cecilia Jernberg from the Swedish Institute for Infectious Disease Control, who conducted the review of those studies.
The presence of a high level of antibiotic-resistant genes in the gut increases the chance these genes could be transferred to pathogenic bacteria, she said. "This could reduce the success of future antibiotic treatments, and potentially lead to new strains of antibiotic-resistant bacteria ."
Ken