D-Ribose and Keto

sebastian16's Avatar


07 Jun, 2016 11:10 PM

There is no shortage of advocates for D-Ribose in the alt. health community.
It's good for sports man and women.
It's good for circulatory and heart conditions.
It seems to give extra energy and ummmpf to virtually everyone.

But D-Ribose is a carb (not an amino acid, as some commentators have erroneously stated)

My presumption is that D-Ribose should be treated as if it were any other carb.
So.. for example, if you aim to keep carbs down to 50 grams per day and you
take 5 grams of d-Ribose with your breakfast, then that leaves you with room
for only 45 grams of carbs the rest of the day.

BUT.... d-Ribose comes as a pure, refined powder.
Probably... eating a gram of d-Ribose is going to pack more carbo punch
than eating a gram of carrot or a gram of rice.
Perhaps... eating a gram of d-Ribose is akin to eating a gram of sucrose,
i.e. refined sugar.

If d-Ribose is considered a refined sugar, then it would be regarded as
off limits by many or most keto pundits.
So what does d-Ribose do to blood sugar ?
Is d-Ribose like refined sugar in terms of it's Glycemic Index ?
Is it like a rice ? Is it like a carrot ?

The answer is a surprise.
d-Ribose *lowers* blood sugar. It's like un-sugar or anti-sugar.
It is half as sweet as sugar, it gives you energy and focus, and it lowers blood sugar.
For confirmation of this do a google search for
"Effect of D-Ribose on Insulin and Blood Glucose: A Chronological Examination "
I found this paper at:

1. Prime Facie it's a better choice than stevia or xylitol etc.
as a sweetener for keto cakes, pastries etc.
2. Prime facie, d-Ribose might be a good choice as a
supplement during the initial 3 or more weeks of keto
adaptation .... since many report having problems with
brain fog and energy levels. .

But i wonder what the effect on ketosis would be if you
had say, 100 grams of d-Ribose during the day ?
Or say... 25 grams of d-Ribose with a given a meal ?
Could d-Ribose kick you out of ketosis ?

Does anyone know the answer to these questions ?

Sebastian :)

  1. 1 Posted by sebastian16 on 07 Jun, 2016 11:17 PM

    sebastian16's Avatar

    Addendum... A question on d-ribose already exists:

    Supplements and recommendations → D-ribose, does it effect insulin or leptin?
    Hi Dr Rosedale, whats your opinion of D-ribose, does it effect insulin or leptin , if not why? and what is it made from

    It does not effect insulin or leptin directly. Taking D-ribose will not get into the cell. Benfotiamine, a fat soluble form of thiamine that converts glucose into ribose intracellularly, and then the ribose itself is a great substrate for RNA (and other important intracellular molecules, and is a much better option in my opinion. Benfotiamine helps to reduce intracellular glycation unlike D-ribose.
    Presumably, ribose must get into the cell.
    Or how else would ribose provide the energy and focus for which it is famous ?
    Nice to know about benfotiamine.

  2. Support Staff 2 Posted by Ken on 07 Jun, 2016 11:25 PM

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    Great to see the Knowledge Base being used...

    It is a go to place for me ..

    Ken/   Rosedale Support Team

  3. 3 Posted by Rimon on 22 Jul, 2016 10:57 AM

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    Hello Sebastian and Ken,

    It seems that D ribose lowers blood sugar, but raises insulin moderately (I don't know why Dr. Rosedale said it didn't).
    It just seems to not increase pancreatic insulin, but it does increase overall insulin.

    I happen to see a lot of studies regarding D ribose showing this effect over and over. For most people, the insulin increase is insignificant comparing to their sugar consumption, so the energy & cardio benefit are worth it…

    -- but those who follow the Rosedale diet are compromising their goals.

    In addition, diabetics and those with high blood glucose respond stronger to D ribose with insulin secretion. Which further proves the point that those who benefit from Rosedale diet should be careful with D ribose.

    It could be the reduction in blood sugar will overcompensate the insulin secretion with the health benefits, but it is unlikely. This is worrying and Dr. Rosedale will tell you that insulin is much more important than blood sugar.

    I support Dr. Rosedale preference to benfotiamine as a way to increase ribose concentration within the cell. You will receive the benefits without the risk assuming you are following Rosedale diet.

    Others may benefit from direct supplementation with D ribose.

  4. Support Staff 4 Posted by Ken on 22 Jul, 2016 11:50 AM

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    Thank you Rimon. Dr. Rosedale, time permitting, may have a response at a later time.

    Ken/   Rosedale Support Team

  5. 5 Posted by sebastian16 on 22 Jul, 2016 02:41 PM

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    I went out and bought D-Ribose and tried it around 10 days ago.
    I found it gave me an energy crash shortly after... like it was sugar.
    I felt so tired.. i wanted to get in bed. I haven't used it since.

  6. 6 Posted by Rimon Nuhi on 22 Jul, 2016 03:05 PM

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    Thanks for your feedback, Sebastian,

    How long did it take for your energy to crash?

    And was the energy effect similar to eating sugar or felt a bitt different?

  7. Support Staff 7 Posted by Ken on 22 Jul, 2016 03:31 PM

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    Thank you Sebastian for the heads-up.

    Ken/   Rosedale Support Team

  8. 8 Posted by Terrance on 30 Aug, 2018 03:30 PM

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    I take D-ribose for chronic fatigue syndrome and am diabetic on Keto and Omad one meal a day. D-ribose is very important to me having any energy. Also liquid magnesium both have transformed my life. I do more in a hour than I did in a week before those two. For me it feels worth if it knocks me out of ketosis. Stuck constantly tired is no way to live. I am going to research the other suoplent mentioned here thanks.

  9. 9 Posted by Margie on 22 Nov, 2020 04:36 PM

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    So, do we count the 5 carbs or not? Sure, it lowers blood sugar but do we count those carbs???

  10. 10 Posted by Kaleb on 05 May, 2021 04:57 AM

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    I think a ketone test should be utilized to answer the question. I don't test myself and I'm sure that I kick myself out sometimes.
    Anybody actually performed testing?

  11. 11 Posted by Michelle Carter on 05 Nov, 2023 11:49 AM

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    Soooooooo I’m still
    Confused! In simple terms ….. can I or can’t I continue my D-ribose supplement while on Keto diet? I usually put one scoop in coffee each morning. Yay or nay, on the D ribose on keto?????? Don’t need all the scientific answers- just yes or no please.

  12. 12 Posted by Holly on 06 Feb, 2024 10:52 AM

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    I take it in the morning in coffee. Have taken it for nearly 20 years due to heart issues. I count it as 5 carbs and it doesn’t knock me out if ketosis.

  13. 13 Posted by Jenny on 17 Apr, 2024 04:09 PM

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  14. 14 Posted by Jonathan Calos on 07 May, 2024 08:28 AM

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    Explore free printable calendars and online calculator tools: https://jocalendars.com/

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