Benfotiamine & Metformin - Should They Be Used Together?

Rachel's Avatar


03 Oct, 2012 11:40 AM

Hello Dr. Rosedale,

I have reactive hypoglycemia that I treat with both your diet and Metformin. Upon searching this forum I found that you suggest Benfotiamine because it converts glucose into ribose, as opposed to lactic acid.

Please clarify how these two medications differ in terms of influence on insulin:
1. You say that Benfotiamine is converted to ribose intracellulary - does that mean Benfotiamine requires insulin to transport the glucose into the cell, at which point Benfotiamine converts glucose into ribose? In that case, is it true that Benfotiamine does not help keep insulin levels down, but instead just works to reduce AGES?
2. I was under the impression that Metformin converts glucose into lactic acid so that insulin isn't raised to usher it into the cell. Is this correct?
3. Should these supplements be used together, or is that unnecessary?

I'm basically hoping to find out if both Benfotiamine and Metformin work to keep insulin levels low, while also working to convert sugar to less harmful substances. I'd like to switch from Metformin to Benfotiamine upon your recommendation- is there a recommended dosage, or would that be dependent upon severity of disease?

Thank you for your expertise. I wish I could clone you. :)

  1. Support Staff 1 Posted by Fiona on 03 Oct, 2012 06:37 PM

    Fiona's Avatar

    We wish we could clone him too! Thank you for allowing your questions to be public, as so many more people learn through reading them. Dr. Ron is not available right this moment, however I know that Metformin is the only diabetic drug he is ok with people taking and that he does recommend if people can afford to, to switch it with Benfotiamine for the reasons that you mentioned.

  2. 2 Posted by Rachel on 08 Oct, 2012 09:46 AM

    Rachel's Avatar

    Thanks for this! I will buy the Benfotiamine and see how that goes. Is there a recommended dosage you're aware of, or should I do a little Google research? (Thought I'd try my luck with you guys first since there's trust established.)

  3. Support Staff 3 Posted by Fiona on 08 Oct, 2012 10:49 AM

    Fiona's Avatar

    Benfotiamine works over time. I will check with Dr. Ron, but thinking transitioning out the Metformin as you introduce the Benfotiamine, but this is a question for Dr. Ron who is not here right now.

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